10 Best Enzyme Cleaner of 2025

Discover the power of enzyme cleaners! Uncover the ultimate solutions for deep, natural cleaning. Dive into our comparison to find the best match for your cleaning needs—eco-friendly and effective!

Updated: June 5, 2025

1
Best Overall
Rocco & Roxie Stain and Odor Eliminator - Rank 1 in Best Enzyme Cleaner of 2025

Rocco & Roxie Stain and Odor Eliminator

  • Effectively removes tough pet stains and odors.
  • Safe for use around pets and children.
  • Works on various surfaces, including carpets.
9.8
(119,435 reviews)
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2
Best Affordable
25% Coupon
Angry Orange Enzyme Pet Cleaner - Rank 2 in Best Enzyme Cleaner of 2025

Angry Orange Enzyme Pet Cleaner

  • Effective on tough pet stains and odors.
  • Pleasant citrus scent masks unpleasant smells.
  • Safe for use around pets and family.
9.6
(28,535 reviews)
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3
Bioda Probiotic Enzyme Cleaner and Deodorizer - Rank 3 in Best Enzyme Cleaner of 2025

Bioda Probiotic Enzyme Cleaner and Deodorizer

  • Effectively tackles tough stains and odors.
  • Suitable for multiple cleaning surfaces.
  • Made in the USA for quality assurance.
9.2
(704 reviews)
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4
25% off + 10% Coupon
Urine B-Gone Enzyme Odor Eliminator, 1 Gallon - Rank 4 in Best Enzyme Cleaner of 2025

Urine B-Gone Enzyme Odor Eliminator, 1 Gallon

  • Effectively removes tough urine odors and stains.
  • Safe for use on various surfaces and fabrics.
  • Suitable for pets and human-related cleaning needs.
8.9
(3,627 reviews)
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5
Bastion Probiotic Enzyme Cleaner One Gallon - Rank 5 in Best Enzyme Cleaner of 2025

Bastion Probiotic Enzyme Cleaner One Gallon

  • Effective at removing tough stains and odors.
  • Natural formula safe for pets and kids.
  • No rinse needed for easy application.
8.6
(576 reviews)
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6
Biokleen Bac-Out Enzyme Stain and Odor Remover - Rank 6 in Best Enzyme Cleaner of 2025

Biokleen Bac-Out Enzyme Stain and Odor Remover

  • Effective on a wide range of stains.
  • Safe, non-toxic formula for households.
  • Eco-friendly and biodegradable ingredients.
8.4
(7,324 reviews)
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7
13% off
Green Gobbler Enzyme Drain Cleaner - Rank 7 in Best Enzyme Cleaner of 2025

Green Gobbler Enzyme Drain Cleaner

  • Effectively breaks down various drain blockages.
  • Controls odors, keeping spaces smelling fresh.
  • Safe for septic systems and environmentally friendly.
8.2
(9,018 reviews)
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Available on Amazon
8
Popular
25% Coupon
BUBBAS Enzyme Cleaner - Pet Odor & Stain Remover - Rank 8 in Best Enzyme Cleaner of 2025

BUBBAS Enzyme Cleaner - Pet Odor & Stain Remover

  • Effectively eliminates tough pet odors and stains.
  • Safe for various surfaces, including hardwood floors.
  • Uses natural enzyme formula for deep cleaning.
8.0
(11,554 reviews)
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Available on Amazon
9
10% Coupon
Kleen Free Enzyme Cleaner Concentrate 128oz - Rank 9 in Best Enzyme Cleaner of 2025

Kleen Free Enzyme Cleaner Concentrate 128oz

  • Versatile cleaner for multiple household uses.
  • Natural enzyme formula effectively removes stains.
  • Concentrate offers economical, long-lasting supply.
7.8
(532 reviews)
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10
Hot Deal
18% off
Enzyme Cleaner 1 Gallon Odor Eliminator - Rank 10 in Best Enzyme Cleaner of 2025

Enzyme Cleaner 1 Gallon Odor Eliminator

  • Effectively eliminates odors and stains.
  • Multi-purpose for residential and commercial use.
  • Made in the USA with quality ingredients.
7.7
(110 reviews)
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Available on Amazon

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Overview of enzyme cleaner

In the quest for a cleaner, fresher home, traditional cleaning products often fall short, especially when it comes to tackling stubborn stains and lingering odors. This is where enzyme cleaners come into play. Unlike conventional cleaners that rely on harsh chemicals, enzyme cleaners use natural enzymes to break down organic matter, making them an eco-friendly and effective option for pet owners, parents, and anyone dealing with everyday messes. Whether you're dealing with pet accidents, food spills, or musty smells, choosing the right enzyme cleaner can transform your cleaning routine, leaving your home spotless and fresh with minimal effort.

Frequently Asked Questions

How does an enzyme cleaner work on pet stains?

Enzyme cleaners work by breaking down the proteins and organic materials in pet stains, effectively eliminating odors and preventing your pets from re-marking the area. They're a great solution for keeping your home fresh and clean without harsh chemicals.

Can an enzyme cleaner be used on carpets?

Absolutely! Enzyme cleaners are safe to use on carpets and can effectively remove tough stains like pet urine, wine, or food spills. They penetrate deep into the fibers, breaking down stains at the source and leaving your carpet looking and smelling fresh.

Are enzyme cleaners safe for all surfaces?

Most enzyme cleaners are versatile and can be used on a variety of surfaces, including fabric, upholstery, and floors. However, it's always a good idea to test a small, inconspicuous area first to ensure the cleaner doesn't cause any discoloration or damage.

How long does it take for an enzyme cleaner to work?

The time it takes for an enzyme cleaner to work can vary depending on the severity of the stain and the product used. Generally, you should allow the cleaner to sit for at least 15-30 minutes to let the enzymes break down the stain effectively. For tougher stains, you might need to let it sit longer or apply multiple treatments.

Can enzyme cleaners help with mold and mildew?

Yes, enzyme cleaners can be effective against mold and mildew by breaking down the organic matter that these fungi feed on. Regular use of an enzyme cleaner can help prevent mold and mildew growth, keeping your surfaces clean and your indoor air quality healthier.